职称：副教授
邮箱：qingxiong@hbut.edu.cn
研究方向：病毒受体与入侵机制
学习和工作经历：
2015.09-2019.06 湖北大学 生命科学学院 生物科学类（学士）
2019.09-2022.06 武汉大学 生命科学学院 微生物学 （硕士）
2022.09-2025.06 武汉大学 生命科学学院 微生物学 （博士）
2025.11 至今 威廉希尔足球官网 威廉希尔足球官网,威廉希尔williamhill 副教授
研究领域：
长期从事病毒受体与入侵机制研究。以逆转录病毒和冠状病毒为主要研究对象，致力于受体的发现与鉴定，系统解析病毒感染与传播的分子机制，并探索病毒防控与治疗的新策略。
代表性论文（#并列第一作者，*通讯作者）
1. Qing Xiong#, Lei Cao#, Chengbao Ma#, M. Alejandra Tortorici#, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu, Alexandra C. Walls, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Davide Corti, David Veesler*, Xiangxi Wang*, Huan Yan*. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature. 2022 Dec;612(7941):748-757.
2. QingXiong#, Chengbao Ma#, Chen Liu, Fei Tong, Meiling Huang, Huan Yan*. ACE2-using merbecoviruses Further evidence of convergent evolution of ACE2 recognition by NeoCoV and other MERS-CoV related viruses. Cell insight. 2024 Jan 30;3(1):100145.
3. Qianyun Liu#, Qing Xiong#, Fanghua Mei#, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai*, Huan Yan*, Yu Chen*, Ke Lan*. Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China. The Innovation. 2022 Jan 25;3(1):100181.
4. Chengbao Ma#, Chen Liu#, Qing Xiong#, Mengxue Gu, Lulu Shi, Chunli Wang, Junyu Si, Fei Tong, Peng Liu, Meiling Huang, Huan Yan. Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition. Cell Discov. 2023 Jun 15;9(1):57.
5. Chen Liu#, YoungJun Park#, ChengBao Ma, Risako Gen, Cameron Stewart, YuCheng Sun, Xiao Yang, MeiYi Lin, Qing Xiong, JunYu Si, Peng Liu, David Veesler*, Huan Yan*. HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor. Nat Microbiol. 2025 Nov; 10(11):2860-2874.
6. ChengBao Ma#, Chen Liu#, YoungJun Park#, Jingjing Tang#, Jing Chen#, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M Alejandra Tortorici, Xiao Yang, YeHui Sun, YuanMei Chen, Xiao Yu, JunYu Si, Peng Liu, Fei Tong, MeiLing Huang, Jing Li, Zheng-Li Shi*, Zengqin Deng*, David Veesler*, Huan Yan*. Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses. Cell. 2025 Mar 20;188(6):1693-1710.
7. YoungJun Park#, Chen Liu#, Jimin Lee, Jack T Brown, ChengBao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K Zepeda, Cameron Stewart, Amin Addetia, Caroline J Craig, M Alejandra Tortorici, Abeer N Alshukairi, Tyler N Starr, Huan Yan*, David Veesler*. Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses. Cell. 2025 Mar 20;188(6):1711-1728.
8. Peng Liu#, MeiLing Huang#, Hua Guo#, Matthew McCallum#, JunYu Si, YuanMei Chen, ChunLi Wang, Xiao Yu, LuLu Shi, Qing Xiong, ChengBao Ma, John E. Bowen, Fei Tong, Chen Liu, Yehui Sun, Xiao Yang, Jing Chen, Ming Guo, Jing Li, Davide Corti, David Veesler*, ZhengLi Shi*, Huan Yan*. Design of customized coronavirus receptors. Nature. 2024 Nov; 635(8040):978-986.
9. Junyu Si#, Yuanmei Chen#, Yehui Sun#, Mengxue Gu, Meiling Huang, Lulu Shi, Xiao Yu, Xiao Yang, Qing Xiong, Chenbao Ma, Peng Liu, ZhengLi Shi, Huan Yan. Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness. Nat Commun. 2024 Oct 14;15(1):8869.
10. Qianyun Liu#, Haiyan Zhao#, Zhiqiang Li#, Zhen Zhang#, Rui Huang#, Mengxue Gu, Ke Zhuang, Qing Xiong, Xianying Chen, Weiyi Yu, Shengnan Qian, Yuzhen Zhang, Xue Tan, Muyi Zhang, Feiyang Yu, Ming Guo, Zhixiang Huang, Xin Wang, Wenjie Xiang, Bihao Wu, Fanghua Mei, Kun Cai, Limin Zhou, Li Zhou, Ying Wu*, Huan Yan*, Sheng Cao*, Ke Lan*, Yu Chen*. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther. 2023 Sep 14;8:347.
11. Chengbao Ma#, Xianying Chen#, Fanghua Mei#, Qing Xiong, Qianyun Liu, Lianghui Dong, Chen Liu, Wenjing Zou, Faxian Zhan, Bing Hu, Yingle Liu, Fang Liu, Li Zhou, Junqiang Xu, Yongzhong Jiang, Ke Xu, Kun Cai*, Yu Chen*, Huan Yan*, Ke Lan*. Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 2022 Dec;11(1):567-572.
12. Huan Yan#, Hengwu Jiao#, Qianyun Liu, Zhen Zhang, Qing Xiong, BingJun Wang, Xin Wang, Ming Guo, LinFa Wang, Ke Lan*, Yu Chen*, Huabin Zhao*. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature Ecol Evol. 2021 May;5(5):600-608.
招生招聘
欢迎对病毒学研究感兴趣的本科生和研究生加入我们的团队! 有意向加入者请将简历发送至qingxiong@hbut.edu.cn。
